Leukocytospermia Is Associated with Poor Semen Quality, Oxidative Stress, and Increased Dna Damage
نویسندگان
چکیده
QUALITY, OXIDATIVE STRESS AND INCREASED DNA DAMAGE Ramadan A. Saleh, The Cleveland Clinic Foundation, Juan G. Alvarez, Beth Israel Medical Center, Harvard Medical School, Essam A. Nada, Sohag Faculty of Medicine, Mohamed H. El-Tonsy, al-Minya Faculty of Medicine, Donald P. Evenson, South Dakota State University, Ashok Agarwal, The Cleveland Clinic Foundation Objective: The incidence of leukocytospermia ranges from 10% to 20% among infertile men. However, the role of leukocytospermia in the pathogenesis of male infertility remains highly controversial. Our study evaluated the relationship between leukocytospermia and standard semen parameters, levels of seminal reactive oxygen species (ROS), and the extent of sperm nuclear DNA damage.
منابع مشابه
Leukocytospermia is associated with increased reactive oxygen species production by human spermatozoa.
To investigate the role of increased seminal leukocytes in enhancing reactive oxygen species (ROS) production by human spermatozoa.A prospective study. Male infertility clinic.Forty-eight infertile men. Standard semen analysis. Assessment of sperm nuclear DNA damage by sperm chromatin structure assay. Incubation of spermatozoa from nonleukocytospermic samples with blood neutrophils. Spontaneous...
متن کاملReactive oxygen species and sperm DNA damage in infertile men presenting with low level leukocytospermia
BACKGROUND Leukocytes contribute directly and indirectly to reactive oxygen species (ROS) production. Although leukocytospermia is defined as the presence of ≥ 1 × 106 white blood cells/mL (WBC/mL) in a semen sample, the presence of less than 1×10(6) WBC/mL (low-level leukocytospermia) can still produce a detectable amount of ROS, impairing sperm function and lowering the chances of pregnancy. ...
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